Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

Dahms, S.O.; Mayer, M.C.; Roeser, D.; Multhaup, G.; Than, M.E.

doi:10.1107/S1399004714027114

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 6
Mechanistic model of heparan sulfate binding by APLP1 E2. (a) Specific recognition of the highly modified nonreducing ends. (b) Register-dependent tethering of APLP1 E2 to continuous heparin chains in various sulfation states.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 3| February 2015| Pages 494-504

doi:10.1107/S1399004714027114

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