view article
Figure 3
(a) Binding sites (sites 1–3) of 4-methylimidazole (4MI) within and near the active site of H64A CA II. 2Fo − Fc electron-density maps are contoured at 1.2σ. Zn is shown as a blue sphere and His64 from wild-type CA II (PDB entry 3ks3 ; Avvaru et al., 2010BB8) is shown as yellow sticks to represent the `in' and `out' conformations. (b) The inhibition by 4MI of CO2/HCO3− interconversion (R1/[E], black) and enhancement of proton transfer (RH2O/[E], red) on H64A CA II.

IUCrJ
Volume 1| Part 2| February 2014| Pages 129-135
ISSN: 2052-2525
doi:10.1107/S2052252514004096