Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation

Martin-Garcia, J.M.; Conrad, C.E.; Nelson, G.; Stander, N.; Zatsepin, N.A.; Zook, J.; Zhu, L.; Geiger, J.; Chun, E.; Kissick, D.; Hilgart, M.C.; Ogata, C.; Ishchenko, A.; Nagaratnam, N.; Roy-Chowdhury, S.; Coe, J.; Subramanian, G.; Schaffer, A.; James, D.; Ketwala, G.; Venugopalan, N.; Xu, S.; Corcoran, S.; Ferguson, D.; Weierstall, U.; Spence, J.C.H.; Cherezov, V.; Fromme, P.; Fischetti, R.F.; Liu, W.

doi:10.1107/S205225251700570X

Figure 4
Electron-density maps displayed around the four disulfide bridges in lysozyme: (a) Cys6–Cys127, (b) Cys30–Cys115, (c) Cys64–Cys80 and (d) Cys76–Cys94. Cysteines and neighboring residues are represented as pink sticks. Left panels, structure-factor amplitude Fourier difference (F_o − F_o) maps at 3σ between our data and the data set collected at LCLS (Fromme et al., 2015

), with red and green contours indicating negative and positive density, respectively. Right panels, 2mF_o − DF_c (light pink mesh, contoured at 1σ) and mF_o − DF_c (red and green meshes, contoured at 3σ) maps.

IUCrJ

Volume 4| Part 4| July 2017| Pages 439-454

ISSN: 2052-2525

https://doi.org/10.1107/S205225251700570X

PHYSICS | FELS

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